The goal scorers were Ryan Giggs and Michael Carrick. The goal of Ryan's is his 150th goal for UNITED.
Meanwhile, The Bundesliga side, this is the first defeat in their debut in Europe's premier club competition this season.
UNITED are now three points clear at the top of Group B with six points. Wolfsburg and CSKA Moscow have three points while Besiktas are bottom with none after their defeat to the Russians in the day's early game.